10 exam-style questions with answers and explanations, straight from our 1,030-question bank. Tap an answer to check yourself. When you're ready, take the scored version in the free practice test.
The Oncology exam has 300 questions and runs 7 hours.
These 10 free Oncology questions are organized by exam domain, so you can see how each part of the Certification in Oncology blueprint is tested. Reveal the answer and explanation under each question.
A patient scheduled for a carboplatin-containing regimen has marked muscle wasting. The creatinine-based laboratory eGFR is 95 mL/min/1.73 m², but a radionuclide clearance study reports an absolute measured GFR of 55 mL/min. Kidney function is stable, and the prescribed carboplatin target AUC is 5 mg·min/mL. Using the most appropriate renal-function measurement, what total carboplatin dose should be prescribed?
Correct answer: C - 400 mg
A 42-year-old woman with regular menstrual cycles is newly diagnosed with metastatic breast cancer involving bone and three small liver lesions. A liver biopsy is ER 95%, PR 70%, and HER2 IHC 0. She has received no anticancer therapy, remains fully active, and has normal bilirubin and hepatic synthetic function. There is no rapid clinical deterioration, and pretreatment ECG and electrolytes are normal. Which first-line systemic regimen is most appropriate?
Correct answer: B - Goserelin, letrozole, and ribociclib
A right hemicolectomy specimen from a 63-year-old shows a moderately differentiated adenocarcinoma extending through the muscularis propria into pericolonic fat. All 24 lymph nodes are negative, margins are clear, and there is no lymphovascular or perineural invasion. There was no obstruction or perforation. Staging CT is negative for metastases, and the tumor is mismatch-repair deficient. What should be recommended after recovery from surgery?
Correct answer: A - Postoperative surveillance alone
After transurethral resection of a solitary bladder tumor, pathology shows high-grade urothelial carcinoma invading the lamina propria. The report specifically states that muscularis propria is absent from the specimen. CT shows no hydronephrosis, enlarged nodes, or distant disease. The patient is medically fit and wishes to preserve his bladder when oncologically appropriate. Before selecting intravesical adjuvant treatment, what is needed?
Correct answer: D - Repeat transurethral resection with muscularis propria sampling
The emergency department requests an oncology consultation for a 36-year-old with gingival bleeding and widespread bruising. Platelets are 18,000/µL, INR is 1.8, and fibrinogen is 85 mg/dL. The peripheral smear contains abnormal promyelocytes with bundles of Auer rods. Platelet and cryoprecipitate support has begun; testing for PML::RARA will not return until tomorrow. Which intervention should be added now?
Correct answer: D - Start all-trans retinoic acid now
Evaluation of an IgG-kappa monoclonal protein reveals 18% clonal bone marrow plasma cells. Hemoglobin is 13.2 g/dL, creatinine is 0.9 mg/dL, and calcium is 9.4 mg/dL. Low-dose whole-body CT shows no osteolytic lesions. Which additional result would establish multiple myeloma under International Myeloma Working Group diagnostic criteria?
Correct answer: C - Two unequivocal focal marrow lesions on MRI, measuring 8 mm and 11 mm
Four weeks after definitive concurrent platinum-based chemoradiation for unresectable stage III lung adenocarcinoma, imaging shows a partial response without progression. Molecular testing identifies an EGFR exon 19 deletion; PD-L1 tumor proportion score is 85%. The patient has recovered from treatment and has no clinical or radiographic pneumonitis. Which post-chemoradiation therapy best fits the molecular findings?
Correct answer: A - Osimertinib
Excisional biopsy of a changing upper-back lesion in a healthy 47-year-old shows invasive melanoma with a Breslow thickness of 1.6 mm and no ulceration. There are no palpable regional nodes or symptoms suggesting distant spread. Wide local excision is planned. Which regional nodal strategy best complements the planned excision?
Correct answer: D - Sentinel lymph-node biopsy with lymphatic mapping
A 62-year-old former smoker taking prednisone for polymyalgia rheumatica develops painless thigh weakness, dry mouth, and constipation. Sensation is intact, and there is no ptosis. Knee reflexes are absent at rest but become readily elicitable immediately after 10 seconds of maximal quadriceps contraction; hip flexion also briefly improves. Which diagnosis best explains the combination of motor and autonomic findings?
Correct answer: B - Lambert-Eaton myasthenic syndrome
Before rituximab-based treatment for diffuse large B-cell lymphoma, hepatitis testing shows negative HBsAg, positive total anti-HBc, and positive anti-HBs. HBV DNA is undetectable and alanine aminotransferase is normal. There is no cirrhosis or prior antiviral treatment. Which plan most appropriately prevents hepatitis B reactivation during and after the anti-CD20 course?
Correct answer: C - Entecavir before rituximab, throughout treatment, and for at least 12 months afterward
The Oncology exam also covers these domains. Drill them in the full free practice test:
The full bank has 1,020 more Oncology questions with explanations.
Continue in the free practice test →
View plans